HOD's Profile : Department of Veterinary Physiology Biochemistry and Pharmacology
Dr Adeolu Alex Adedapo DVM, MSc, PhD (Ibadan), MCVSN, FIIA
Adeolu Alex Adedapo, is a Senior Lecturer in Veterinary Pharmacology and Toxicology at the University
of Ibadan, Nigeria and an Adjunct Professor of Biological Sciences, Wesley University of Science and Technology, Ondo, also in Nigeria. He is currently Head, Department of Veterinary Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Ibadan where he teaches Pharmacology and Toxicology at the undergraduate and postgraduate levels. He also handles research in Phytotoxicology and Ethnopharmacology, as well as supervision of both undergraduate and postgraduate projects. He has well over 70 publications to his credit. He is also a Fulbright Scholar.
Adeolu Adedapo holds a Doctor of Veterinary Medicine degree in 1988 from the University of Ibadan.
He obtained a Masters Degree (M.Sc) in Veterinary Pharmacology in 1995 and Doctor of Philosophy (PhD) in Veterinary Pharmacology in the year 2002, from the same university. An alumnus of Haggai Institute of Leadership, Singapore, Adeolu Adedapo is happily married with children.
Focus of my Research
My initial research focus includes chemotherapy of some parasitic diseases in Nigeria using cattle,rabbits and chickens as animal models. A study was carried out to assess the types of species prevalent in some states in Southern Nigeria and at the same time identify the common coccidiostats commonly administered to curtail this disease.
The need for accurate diagnosis of this disease on the farm is important as this will help to quickly control the infection. Hence, a simple technique of faecal sampling for Coccidia agent was carried out. One of the major problems in the chemotherapy of avian coccidiosis is the development of drug resistance to anticoccidials by the parasitic agent. A review study was carried out stressing the need for using several anticoccidials with differing chemical profiles. This principle also known as ‘shuttle’ if put to use will effectively rob the coccidia of the opportunity to develop resistance to any chemical entity.
My research efforts in trypanosomosis include the assessment of currently used trypanocidal agents in Nigeria in terms of their efficacy and potency. Comparative efficacy study of Homidium bromide (Ethidium®), diminazene aceturate (Berenil®) and their combination was conducted on New Zealand white rabbits experimentally infected with T. congolense. The higher efficacy of trypanocide combination compared to single drug therapy and the usefulness of drug combination as a temporary measure to minimizing development of drug resistance was highlighted. The use of medicinal plants as alternative means of combating diseases in tropical environment is gaining tremendous attention. In the last ten years or so, the focus of my research has been in the area of Phytotherapy with specific attention on anti-inflammatory, analgesic and anti-oxidant studies. For instance, the phenolic, biological, antioxidant as well as antibacterial properties of many plants were evaluated with strong conviction that their use for ethnopharmacological purpose is largely justified.
Also, anthelmintic efficacy of E. hirta and Vernonia amygdalina were assessed in dogs and these plants were very potent in this regard. Attention was also paid on the safety of some plants used for medicinal purpose and it was concluded that a lot of caution should be exercised in this regards. More recently however, the research focus is on cardiovascular pharmacology with emphasis on renal pathophysiology and the relationship to high blood pressure.